Internalized gap junctions are degraded by autophagy

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Internalized gap junctions are degraded by autophagy

Direct intercellular communication mediated by gap junctions (GJs) is a hallmark of normal cell and tissue physiology. In addition, GJs significantly contribute to physical cell-cell adhesion. Clearly, these cellular functions require precise modulation. Typically, GJs represent arrays of hundreds to thousands of densely packed channels, each one assembled from two half-channels (connexons), th...

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Gap Junctions

Gap junctions are sites of intercellular communication where cells are interconnected by small aqueous channels (Figure 1b). The term is morphological, for in transmission electron micrographs of thin sections, the unit membranes of the joined cells are seen to remain separated by a gap of about 2 nm (Figure 1a, inset). The gap of gap junctions distinguishes them from tight junctions, or zonula...

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ژورنال

عنوان ژورنال: Autophagy

سال: 2012

ISSN: 1554-8627,1554-8635

DOI: 10.4161/auto.19390